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BARRX (HALO ablation)  |  Diagnosis
Barrett's Risk Factors

A long-standing reflux is a major risk factor for the development of Barrett's esophagus. Other risk factors are age, white and male population, obesity, cigarette smoking and possible alcohol consumption.

Progression to Cancer

The information below is intended to provide you with a general understanding of the progression of Barrett's esophagus to cancer. Refer to a medical professional for more detailed information and to address any questions you may have.

Barrett's esophagus has three stages prior to its progression to esophageal cancer: 11-12

1. Intestinal metaplasia (IM) - The tissue cells have begun to change genetically and the tissue resembles the red intestinal lining rather than the normal and healthy pink esophagus lining. At this stage, a person has Barrett’s esophagus, but has not developed Dysplasia, the next stage.  
2. Low-grade Dysplasia (LGD IM) – Less than 50% of the abnormal cells have begun to change in size, shape, or organization and may show an increase in their growth rate. The cells are contained within the lining of the esophagus and have not spread to other areas.  
3. High-grade Dysplasia (HGD IM) – As with LGD, the abnormal cells reside within the lining of the esophagus. But more than 50% of these cells do demonstrate a higher increase in abnormal growth rate and pattern.  
4. Adenocarcinoma (Esophageal Cancer): When the abnormal cells have a rapid and uncontrolled growth rate. The cells also invade the deeper layers of your esophagus and may spread beyond that. These cells can develop into malignant tumors.

Adenocarcinoma can also be classified in different stages or categories. Contact your physician for more information.


The above introduction to esophagus is provided compliments of BARRX.